Skip to main content Access Home Alt+0 Navigation Alt+1 Content Alt+2 Search Search the WHO.int site Submit Advanced search Navigation Home Health topics Data Media centre Publications Countries Programmes Governance About WHO Language عربي 中文 English Français Русский Español International Programme on Chemical Safety Menu IPCS HomeHealth impacts of chemicalsTools for assessing chemical risksPoisons information, prevention and managementChemical incidents and emergenciesCapacity buildingChemical risk assessment networkPublications Global assessment of the state-of-the-science of endocrine disruptors WHO/PCS/EDC/02.2Table of contents Detailed Table of Contents and Prefacepdf, 504kb Chapter 1: Executive Summarypdf, 472kb Purpose and Scope of Document Endocrine Mechanisms of Action Dose-Response Relationships Effects in Wildlife Human Health Effects Exposure Causal Criteria and Weight of Evidence for Effects Resulting from Exposure to EDCs Chapter 2: Introduction/Backgroundpdf, 488kb General Background Generic Issues Mechanisms of Endocrine Disruption in Humans and Wildlife Dose-Response Relationships Exposure Issues Chapter 3: Endocrinology and Endocrine Toxicologypdf, 2.15Mb Introduction to Endocrine Systems Scope and Terminology The HPG Axis in Mammals The HPA Axis The HPT Axis The Pineal Gland: A Photoperiodic Transducer Interactions of the HPG Axis with Other Endocrine Systems Growth in Understanding of Endocrine Systems Developmental/Programming Effects of Endocrine Systems Nonreproductive Effects of Sex Steroids Endocrine Cross Talk and Endocrine Disruptors Modes of Action and Phenotypic Outcomes of EDC-Related Developmental and Reproductive Toxicities EDC Modes of Action for Carcinogenesis - The Effect of Atrazine EDC-Related Modes of Action in Neurotoxicity EDC-Related Modes of Action in Immunotoxicity Basis for Attribution of Effects to Endocrine Disruption Chapter 4: Wildlifepdf, 2.67Mb Mammals Birds Reptiles Amphibians Fish Invertebrates Uncertainties and Research Needs Chapter 5: Human Healthpdf, 683kb Reproduction Neurobehavior Immune System Cancer Other Endocrine Systems Potentially Vulnerable to EDCs Chapter 6: Exposure of Selected Potential EDCs in Humans and Wildlifepdf, 2.46Mb Introduction General Exposure Issues Case Studies Measurement of Exposure to EDCs Summary Annex Ipdf, 2.60Mb Chapter 7: Causal Criteria for Assessing Endocrine Disruptors - A Proposed Frameworkpdf, 504kb Introduction Elements of the Proposed Framework Overall Strength of Evidence Illustrative Examples - Status and Trends Observations Illustrative Examples - Nonstatus and Trend-Type Observations Chapter 8: General Conclusions and Research Needspdf, 444kb Referencespdf, 706kb Front cover pdf, 253kb Back coverpdf, 253kb You are here: International Programme on Chemical Safety Publications New and emerging scientific issues for chemicals assessment Quick Links Sitemap Home Health topics Data Media centre Publications Countries Programmes and projects Governance About WHO Help and Services Contacts FAQs Employment Feedback Privacy E-mail scams WHO Regional Offices WHO African Region WHO Region of the Americas WHO South-East Asia Region WHO European Region WHO Eastern Mediterranean Region WHO Western Pacific Region © WHO 2017Back to top Email Address Sign up for WHO updates
