SSRIs: Uses, Side Effects, and Facts

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Types of SSRIs

The FDA is in charge of deciding which medications are safe and effective for which reasons. The following SSRIs are approved to treat depression, anxiety, and other mood disorders:

● Citalopram (Celexa)

● Escitalopram (Lexapro)

● Fluoxetine (Prozac)

● Fluvoxamine (Luvox, Luvox CR)

● Paroxetine (Paxil, Paxil CR)

● Sertraline (Zoloft)

Side Effects

Most people who use SSRI antidepressants don’t have major problems, but every kind of medical treatment carries some risk. The possible side effects of these antidepressants include:

Insomnia

Headaches

Rash

● Blurred vision

● Drowsiness

Dry mouth

● Agitation or nervousness

● Feeling dizzy

Pain in the joints or muscles

Upset stomach, nausea, or diarrhea

● Reduced sexual desire

● Problems with erection or ejaculation

Some people, especially children and young adults, may be more likely to have suicidal thoughts when they take SSRIs. Studies show that when compared to results from taking a placebo, chances of having suicidal thoughts doubled -- from between 1% and 2% to between 2% and 4% -- when taking any kind of antidepressant, including an SSRI. If you have thoughts of hurting yourself while taking an SSRI, call 911.

There are also important safety issues to consider about SSRIs. Although it’s rare, if too much serotonin accumulates in your system, you can develop a condition called serotonin syndrome. This happens most often if two different medications that increase serotonin are combined.

SSRIs can also have dangerous interactions with some medicines, both prescription and over-the-counter, including herbs and supplements. Before starting on an SSRI, make sure to tell your doctor all the different kinds of medications and supplements you're taking.

Since all SSRIs work in a similar way, the side effects tend to be similar no matter what kind you take. But each SSRI has a different chemical makeup, so it’s possible that if you’re having side effects from one, you may not experience as many or any at all if you switch to another.

While some people do have side effects, others do not, and in many cases, the side effects disappear after a few weeks of treatment. It’s important to work with your doctor to find a medication that’s right for you.